ZILRETTA® (triamcinolone acetonide extended-release injectable suspension)
Efficacy and Safety of ZILRETTA for Pain in Patients With Glenohumeral Osteoarthritis
Summary1
Condition: Shoulder osteoarthritis
Treatment: ZILRETTA® (triamcinolone acetonide extended-release injectable suspension), triamcinolone acetonide injectable suspension immediate release (TCA-IR), placebo
Male & Female
Age Range: 50–80 years
32 Locations
Phase 1
What is this study about?
- This study is exploring whether ZILRETTA, a long-acting corticosteroid injection, can help reduce shoulder pain caused by glenohumeral osteoarthritis (OA), a form of arthritis that affects the main joint of the shoulder. Researchers want to understand how well ZILRETTA relieves shoulder pain compared with standard steroid injections and placebo (a saline injection). The findings may help doctors improve pain management and quality of life for people living with shoulder OA1
What treatment is being studied?
- The study is evaluating ZILRETTA, a long-acting form of the corticosteroid triamcinolone acetonide, designed to provide extended pain relief following a single injection into the joint1
- How it works: ZILRETTA uses a special extended-release formulation that slowly delivers medicine inside the joint, helping control pain for several weeks or even months
- How it’s given: ZILRETTA is given as a single intra-articular (IA) injection, meaning that it’s injected directly into the shoulder joint where arthritis causes pain1
- The study compares ZILRETTA with two other injections:1
- TCA-IR: a standard corticosteroid that provides shorter-term pain relief
- Placebo (normal saline): an inactive injection used to compare effects
What will happen during the study?
- About 250 adults with shoulder osteoarthritis will be randomly assigned to receive one injection of either ZILRETTA, TCA-IR, or placebo (saline) in the affected shoulder1
- After the injection, participants will have regular check-ups over 24 weeks to track pain relief, shoulder function, and safety. They’ll record daily pain and sleep quality in an electronic diary and have physical exams, lab tests, and X-rays at certain visits1
How can I learn more?
If you’d like to learn more about this study or find out whether you may be eligible to participate, talk to your healthcare provider, reach out to the study team at your local research center, contact jack.castaneda@pacira.com.
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